Fioricet is prescribed primarily for tension headaches, but can also be used for migraines or managing fever and pain in combination. Generally, Fioricet is used when over-the-counter medications have failed to adequately manage headache pain.

People who use Fioricet are primarily people who suffer from tension headaches or migraines. However, a small portion of people using Fioricet may be using them recreationally or to get high.

Women are more likely than men to be diagnosed with chronic migraines and therefore are more likely to receive a prescription of Fioricet. People who receive treatment for migraine are often slightly older and report more severe symptoms.